Properties (1)
Parent
  • Misophonia MOC
context

  • the larger context of this major topic is in the linked parent note
  • this note is to hold everything related to the treatment of Misophonia including existing, proposed, or potential approaches.
  • see the outline guide for tips on assigning and segmenting notes here.
  • a note belongs here if it meets the one or more of the Following:
    • describes a case study/ clinical trial using method to treat people with Misophonia (under the header “treatment outcomes”)
    • describes a proposed method of treating Misophonia (under the header “potential treatments”)
  • a note does NOT belong here if it meets one of the following
    • uses treatment outcomes in a case/trial as a means to support/refute a model of Misophonia.
      • instead, make reference to the treatment outcome here and then give a brief mention of its relevance to a model with a block link to the model note page.


1. what works summary

2. Treatment Mechanisms (How Interventions Are Thought to Work)

misc

app based treatment of Misophonia and implications of a lack of mediation effects

In a 2025 RCT, Podoly et al. tested a 15-day mHealth intervention (GGanger) targeting anger-related cognitions in 85 adults with misophonia, comparing immediate vs delayed app use across baseline, post, and 1-month follow-up. The intervention reduced anger rumination, metacognitions, and one misophonia measure relative to control, with broader within-group improvements maintained after app use. Mediation was not supported, suggesting symptom reduction may reflect mechanisms beyond the targeted cognitive processes. From this the authors claim the GGanger shows promise as a scalable, low-cost intervention for misophonia symptoms and anger-related cognitions, but that the mechanisms underlying symptom reduction remain unclear and may involve cognitive processes beyond those specifically measured in this study. (Podoly et al., 2025).

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emotional dysregulation facets predicting and identifying Misophonia and as targets for future interventions

In a 2024 study, Dixon et al. characterized and tested the unique predictive role of emotion dysregulation facets in misophonia symptoms across sound sensitivity, emotional/behavioral reactions, and functional impairment domains in a probability-based national sample. They found that clinical misophonia was associated with broadly elevated emotion dysregulation, and that specific DERS-16 facets, particularly Clarity, Goals, and Impulse, uniquely predicted misophonia reactions and impairment above demographics and stress. From this they concluded that emotion dysregulation is a robust and clinically meaningful feature of misophonia and that targeting specific regulatory capacities (clarity, goal engagement, impulse control) may improve treatment outcomes (Dixon et al., 2024).


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    network analysis finding cog-affective relationships support CBT principles

    Using EBIC gLASSO network analysis on Duke Misophonia Questionnaire (DMQ) data from 144 adults with varying misophonia severity, Shan et al. (2024) identified strong positive partial correlations between the cognitive and affective response subscales, as well as between the impairment and beliefs subscales, in the overall misophonia network. The authors interpreted these patterns as aligning with the principles of cognitive behavioral therapy (CBT) and with cognitive theories of psychopathology, which hold that maladaptive beliefs actively shape emotional and behavioral dysfunction. They concluded that these network findings provide indirect support for CBT-based approaches in misophonia treatment, noting that prior CBT interventions have shown promising results and that targeting both cognitive responses related to affective reactions and beliefs about the condition may be clinically important (Shan et al., 2024).

  • exposure

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    McMahon 2024 showing an instance of exposure helping treat Misophonia

    in a 2024 study testing the unified protocol to treat Misophonia, the authors have an interesting take on the use of exposure in Misophonia treatment. The authors suggest that building emotion regulation skills prior to engaging in exposure may explain why several patients showed large symptom improvements in later treatment sessions. Although exposure has been viewed negatively in misophonia treatment, patients responded positively in this study. Many endorsed core beliefs that their distress was intolerable and unmanageable without avoidance. The UP’s exposure module allowed patients to test these beliefs by confronting trigger sounds while actively using learned skills, consistent with an inhibitory learning model rather than habituation. The authors note that habituation-based approaches may reinforce maladaptive beliefs, whereas skill-based exposures create new learning experiences. Patients were receptive to exposures because they were framed as opportunities to practice skills in challenging situations, and many felt prepared by the time they reached this module. Those with less confidence benefited from flexibility in selecting exposure tasks. (McMahon et al., 2024)

    3. Treatment Modalities — Behavioral & Psychological

    behavioral

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    review of clinical implications across Misophonia CBT studies

    Reviewing seven CBT-for-misophonia studies, Aazh (2026) concluded that CBT may be considered as a treatment option across a range of settings and delivery formats, including individual, group, telehealth, and audiologist-delivered interventions. Clinicians should be aware of high psychiatric comorbidity in some populations and use comprehensive assessment and individualized formulation; for patients who remain impaired after CBT, broader strategies may be needed, including support for educational, occupational, and family accommodations and clinical documentation of misophonia impact. The author concluded that a balanced approach is required, pairing appropriate accommodations with evidence-based intervention so that reliance on avoidance does not inadvertently maintain symptoms (Aazh, 2026).


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    Review of variability in treatment outcomes across Misophonia studies

    In a systematic narrative review of seven CBT-for-misophonia studies spanning case reports, observational designs, open trials, and RCTs, Aazh (2026) reported that CBT was generally associated with improvements in severity, distress, anger, functional impairment, and coping, but that magnitude and consistency varied substantially. The strongest effects came from RCTs (Jager et al., 2022 ; Lewin et al., 2026), while single-case designs showed variable response (e.g., recovery rates of 43.8%, 42.3%, and 9.1% in Roushani and Mehrabizadeh Honarmand, 2021), and a meaningful proportion of participants remained clinically significantly impaired after treatment (e.g., 22% in Aazh, Najjari and Moore, 2024). The author concluded that recovery following CBT exists on a continuum rather than a simple success/failure distinction (Aazh, 2026).


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    Scoping Review of CBT for Misophonia- Feasibility Established, Efficacy Not Yet

    In a 2026 study, Detroy conducted a focused scoping review of CBT applications to misophonia by synthesizing 14 in-depth studies and summarizing 16 additional reports drawn from a PRISMA-ScR-guided search yielding 30 included publications. They found that CBT-family interventions, spanning ERP, counterconditioning, inhibitory-learning-informed procedures, standardized group packages, and service-based repertoires, were generally feasible to deliver and often associated with reductions on misophonia-specific measures, though designs were mostly uncontrolled with small samples and heterogeneous measurement. From this they concluded that CBT-family procedures are deliverable and potentially helpful for misophonia while falling short of firm efficacy claims, and that future studies should adopt core outcome batteries, specify procedures at a granular level, and test which components contribute uniquely to clinically meaningful change (Detroy & Norena, 2026).

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    the waves of CBT in misophonia research

    Detroy and Norena (2026) conducted a scoping review of Cognitive-Behavioral Therapy (CBT) applications to misophonia, following PRISMA guidance for scoping reviews and synthesizing 30 included publications, 14 of which were described in depth. They organized the methods used across these studies into four historical waves: a first, behavioral wave built from classical and operant conditioning (exposure and response prevention, counterconditioning, relaxation, stimulus manipulation), a second, cognitive wave addressing appraisals (inhibitory-learning-oriented exposure, attentional training, cognitive restructuring, the Unified Protocol), and a third wave (Acceptance and Commitment Therapy, Dialectical Behavior Therapy, Mindfulness-Based Cognitive Therapy) emphasizing acceptance, mindfulness, and values-based action across diagnoses; a fourth wave, used inconsistently in the broader literature to describe well-being- or compassion-focused, technology-enabled process-based care, was noted but not tied to any specific misophonia protocol reviewed. The authors concluded that because each major CBT method was shaped by a different disorder's logic, redeploying wave-specific techniques to misophonia without adaptation risks missing what is distinctive about the condition (Detroy & Norena, 2026).


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    predictive coding model suggests manipulation of sensory precision and expectations could act as a form of treatment in Misophonia and tinnitus

    in there 2026 review, Melanthiou proposes that operating under a predictive coding error model of Misophonia and tinnitus, altering sensory precision and expectations, through combined sound-based therapies and cognitive restructuring, can rebalance bottom-up and top-down processing, thereby reducing the salience and autonomic reactivity to auditory stimuli in a way that is empirically testable. (Melanthiou et al., 2026)


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    Machine Learning-Identified Connectivity Markers Dissociating Misophonia from Hyperacusis Comorbidity

    In a 2026 study, Ajmera attempted to identify neural connectivity-based markers of misophonia using an optimized machine learning framework applied to resting-state fMRI data from 76 university students (ages 18–25) categorized into misophonia-only, misophonia-with-hyperacusis, and control groups based on structured clinical interviews and established questionnaires. They found that both misophonia-only and comorbid groups showed altered connectivity in salience, somatomotor, and frontoparietal control networks, with misophonia-only specifically showing subcortical basal ganglia disruptions and the comorbid group showing unique visual network alterations. From this they concluded that core misophonia-related brain alterations persist despite hyperacusis comorbidity, that subcortical connectivity dissociates the two conditions, and that the findings support psychology-based (CBT) therapy targeting dysfunctional connectivity in salience and control circuits for treating misophonia. (Ajmera et al., 2026)


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    app based treatment of Misophonia and implications of a lack of mediation effects

    In a 2025 RCT, Podoly et al. tested a 15-day mHealth intervention (GGanger) targeting anger-related cognitions in 85 adults with misophonia, comparing immediate vs delayed app use across baseline, post, and 1-month follow-up. The intervention reduced anger rumination, metacognitions, and one misophonia measure relative to control, with broader within-group improvements maintained after app use. Mediation was not supported, suggesting symptom reduction may reflect mechanisms beyond the targeted cognitive processes. From this the authors claim the GGanger shows promise as a scalable, low-cost intervention for misophonia symptoms and anger-related cognitions, but that the mechanisms underlying symptom reduction remain unclear and may involve cognitive processes beyond those specifically measured in this study. (Podoly et al., 2025).


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    McMahon 2024 showing successful misophonia treatment via a unified protocol

    In a 2024 pilot study, McMahon et al. evaluated misophonia treatment using the Unified Protocol (UP), a transdiagnostic CBT targeting emotional intolerance and avoidance. Study 1 showed moderate to high acceptability, significant reductions in emotional/behavioral misophonia responses, anxiety, and anger, small improvements in symptoms and severity, no effect on depression, and medium improvements in maladaptive beliefs (DMQ). Study 2 demonstrated high acceptability and perceived helpfulness, with large effects on emotional/behavioral responses, misophonia severity, and anxiety; medium effects on symptoms and anger; small effects on depression; and maintained or increased gains at follow-up. The authors concluded that the UP is a feasible, acceptable, and promising intervention, particularly effective in reducing emotional reactivity and avoidance. (McMahon et al., 2024)


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    Childhood misophonia as a family-impacting CBT-amenable syndrome

    In a 2024 study, Guzick investigated the clinical presentation and functional impairment of childhood misophonia by conducting and thematically analyzing focused interviews with 20 youth-parent dyads. They found transdiagnostic cognitive behavioral processes including avoidance, anticipatory anxiety, hypervigilance, automatic negative attributions, escape urges, and aggression, alongside secondary emotional consequences and significant impairment in family, school, and social domains. From this they concluded misophonia is an emotionally exhausting syndrome affecting entire family systems, with several promising CBT treatment targets best delivered through modular or process-based frameworks emphasizing family-based components (Guzick et al., 2024).


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    Spencer 2023 findings on trait mindfulness and cognitive emotional regulation in pediatric Misophonia

    In a 2023 study, Spencer and colleagues examined trait mindfulness and cognitive emotion regulation as candidate psychological mechanisms in pediatric misophonia using a cross-sectional correlational and moderation design in 102 youth. They found that greater misophonia severity was associated with lower trait mindfulness and greater maladaptive CER (especially self-blame), and that trait mindfulness uniquely predicted misophonia features and buffered the association between misophonia severity and peer relationship functioning. From this they concluded that trait mindfulness and, to a lesser extent, self-blame are potentially relevant processes in pediatric misophonia and represent candidate targets for psychosocial intervention (Spencer et al., 2023).


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    Mattson 2023 on CBT and treatment outcomes in Misophonia

    In a 2023 review of existing treatment approaches to misophonia, Mattson et al. found that cognitive-behavioral therapy (CBT), particularly in group-based formats, appears to be the most promising intervention, with moderate to large effect sizes reported in the only randomized controlled trial. However, the field still lacks clarity regarding which specific components of CBT, such as exposure, relaxation training, or cognitive reappraisal, are most effective in reducing symptoms. While exposure-based approaches have shown some benefit, the authors suggest that models based on inhibitory learning may be more appropriate than traditional habituation frameworks. Additionally, there is preliminary evidence supporting the potential utility of Acceptance and Commitment Therapy (ACT), Dialectical Behavior Therapy (DBT), and pharmacological interventions in specific clinical contexts. (Mattson et al., 2023)


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    idea of using altered trigger stim in therapeutic interventions

    • Siepsiak et al., 2023 brought up an interesting cognitive approach to dealing with miso that being the modification of Misophonia triggers for therapeutic purposes. basically using the sound swapping method from (Samermit et al., 2022) to create triggers with non triggering associations to help break the Misophonic response
      • (ex: pair crunching with a video of running in the snow. )
      • they also bring up the idea of having Misophonics imagen that trigger sounds are coming from a non trigger source. Is also an interesting example of the role of context on miso symptoms (Siepsiak et al., 2023)

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    diverging future directions for Misophonia based on the importance of depending on the top down or bottom up nature of of Misophonic responses

    One of the motivations of a 2022 study was to disentangle the nature of the Misophonic responses as either being a top down or bottom up process. the authors discuss potential lines of treatment focus based on these possible observations. they hold that if the evidence supports role of acoustic cues as important, solutions should modify acoustic properties of triggers. is top down properties turn out to be the driver, interventions should disrupt the associative link with each trigger. (Savard et al., 2022)

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    A 2022 study looked at the specificity of Misophonic responses, using a signal to noise paradigm. on trials where the source of sounds were identified, Misophonic participants reported greater aversiveness then controls, with a similar but weaker trend for generally aversive sounds. from this the authors suggest that interventions  might benefit from focus on braking the associative links with specific trigger sounds. (Savard et al., 2022)

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    Roushani & Honarmand 2019 case study of 3 college students showed supports CBT for Misophonia

    A 2019 single-case study of three college students with misophonia found that CBT was associated with reductions in anger for two participants, with improvements maintained at follow-up, while the third participant showed minimal improvement and some loss of gains over time. Visual and clinical indices indicated improvement for most participants across intervention and follow-up stages. The authors concluded that CBT reduced anger symptoms in individuals with misophonia and that reduced adherence to exercises over time may weaken treatment effects.


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    Schneider & Arch, 2017 case of Misophonia using mindfulness

    In a 2017 case study of a 17-year-old male, Schneider and Arch implemented a 10-session mindfulness- and acceptance-based treatment for misophonia integrating ACT (values, cognitive fusion, acceptance) and DBT (chain analysis, non judgmental-ness, and opposite action through physical relaxation), along with psychoeducation, trigger monitoring, and relapse prevention. Treatment led to significant reductions in misophonia severity, decreased emotional reactivity and behavioral urges, and maintained or further improved outcomes at 6-month follow-up, with improved distress tolerance even when one trigger’s intensity returned to baseline. The authors concluded that ACT- and DBT-derived strategies are feasible, efficient, and tolerable for misophonia, with improvements driven by increased psychological flexibility, reduced cognitive fusion, reduced avoidance, and particularly the use of opposite action via physical relaxation.(Schneider & Arch, 2017)


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    Schroder 2017 findings on the use of CBT to treat Misophonia

    In a 2017 study ( the authors claim it the first treatment study for Misophonia) of 90 patients, Schröder et al. demonstrated that group CBT is an effective treatment for misophonia, with 48% meeting response criteria and 9% achieving remission. Symptoms significantly decreased (mean A-MISO-S from 13.6 to 9.1), with no improvement during the waitlist period. Greater baseline severity and the presence of disgust (vs. anger alone) predicted better outcomes (OR = 2.576, p = .038). The authors concluded that CBT techniques like counterconditioning and stimulus manipulation effectively target core misophonia symptoms. (Schröder et al., 2017)


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    McGuire 2015 case study of successful Misophonia treatment via CBT

    In a 2015 case study of two youths, McGuire and colleagues described a then-novel cognitive-behavioral treatment for misophonia that included psychoeducation, development of an individualized trigger hierarchy, and graduated exposure with response prevention (ERP) in which sound exposures were systematically intensified and avoidance or aggressive responses were prevented. The intervention also incorporated cognitive restructuring to address maladaptive beliefs about trigger sounds, stepwise reduction of family accommodation, use of reinforcement strategies (for the younger child), and relapse prevention planning. Both youths demonstrated reductions in misophonia severity on objective rating scales. The authors concluded that CBT incorporating ERP and cognitive restructuring may significantly reduce misophonia symptoms in youth, that habituation through exposure is a key mechanism, and that reducing family accommodation is a critical component of effective treatment. (McGuire et al., 2015)


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    a 2015 case study showed marginal improvements in Misophonic physical symptoms using a counterconditioning approach to treat reflexive muscle resposnes to a specific trigger

    In a 2015 case report, Dozier presented the results of a counterconditioning approach to treating misophonia. Operating under the framework of misophonia as a conditioned reflex disorder, Dozier employed the Neural Repatterning Technique (NRT) in combination with Progressive Muscle Relaxation (PMR), delivered via a custom mobile app. The intervention paired individualized trigger sounds with positive stimuli, such as soothing music. Over the course of seven days, the patient's physical reflex response was significantly reduced, and her emotional responses also diminished, even though they were not directly targeted. Based on these outcomes, Dozier proposed that this supported a model of misophonia in which the emotional response follows from an initial physical reflex. (Dozier, 2015)


    # 4. Treatment Modalities — Pharmacological

    5. Treatment Modalities — Audiological

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    Case of incidental improvement of Misophonia symptoms via Risperidone

    in a 2022 report, Pan et al describe the case of a patient who’s Misophonia symptoms improved following a Risperidone treatment. the patient was a 32-year-old male with ASD, intellectual disability, generalized anxiety disorder, and schizoaffective disorder who was Admitted via the emergency department for acute-onset paranoia and delusions during an outpatient-initiated olanzapine tape. During the course of treatment, Risperidone was administered and incidentally the patient reported reductions in existing Misophonia symptoms at a time when no other pharmacological changes were occurring. this reduced severity is further indicated by a change in his AMISOS-R scores from 31 (sever Misophonia ) to 5 ( sub clinical). although symptoms improved they di not disappear completely, and the authors urge future research to use clinical control trials to evaluate the efficacy of this approach, as the effects reported were not predicted and the mechanism by which the drug could have improved Misophonia symptoms is unknown (Pan et al., 2022).


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    2014 report of successful Misophonia treatment using tinnitus retraining therapy

    In a 2014 study, the Jastreboffs' proposed and evaluated a treatment approach for decreased sound tolerance (DST), distinguishing between hyperacusis and misophonia and targeting each with tailored protocols within the framework of Tinnitus Retraining Therapy (TRT). Hyperacusis was treated through gradual sound enrichment to reduce central auditory gain, while misophonia was addressed using behavioral conditioning techniques to weaken maladaptive reflexive responses to specific sounds. Their clinic at Emory University treated 201 patients using these methods, achieving significant improvement in 82% of cases overall, including 80% of those with hyperacusis and 83% of those with misophonia, thereby providing strong clinical support for the neurophysiological mechanisms underlying these conditions. (Jastreboff & Jastreboff, 2014)

  • 6. Treatment Modalities — Neurostimulation

    stimulation in absence of triggers

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    Dheerendra 2025 ccPAS Misophonia treatment protocol

    in a 2025 theoretical proposal paper, Dheerendra proposes that Administration of a ccPAS protocol consisting of activating the post-synaptic area (M1) before the pre-synaptic orofacial motor cortex (PMv) is expected to reduce the hyperactivity previously observed in these regions in individuals with misophonia, thereby reducing misophonic distress. Basically, they suggest this approach could reduce the proposed hyper mirrioing from the Kumar model, thus treating the symptoms of Misophonia ((Dheerendra et al., 2025))

    stimulation before trigger exposure

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    possible miso treatment based off symptom provocation procedure used in OCD using dTMS

    One potential treatment approach, adapted from existing OCD protocols, would be to intentionally expose misophonic individuals to trigger sounds immediately before applying neurostimulation. (Neacsiu et al., 2022) rationale is that activating the circuits implicated in misophonia may make them more amenable to modulation during stimulation. A follow-up strategy could involve applying excitatory stimulation to regions that help downregulate the amygdala, insula, or ACC, or alternatively using inhibitory stimulation over areas such as the SMA, PMv, STG, or vmPFC. Another variation of this paradigm would be to present trigger sounds during the stimulation session itself.

    stimulation during trigger exposure

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    possible miso treatment approach using stim and emotional regulation skills

    A potential treatment approach for misophonia is to combine neurostimulation with concurrent trigger exposure and targeted coaching in emotional regulation strategies. In this model, participants would be guided through techniques such as cognitive distancing while hearing trigger sounds, allowing them to practice regulating their responses in real time. Simultaneously, excitatory stimulation could be applied to regions involved in emotion regulation, while inhibitory stimulation is directed toward areas that tend to be hyperactive in misophonia. This paired approach aims to strengthen regulatory circuits and dampen maladaptive responses as they are occurring. (Neacsiu et al., 2022)

    7. Combined / Multimodal Treatments

    Behavioral + pharmacological

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    A 2024 case series gives three descriptive case studies of individuals with misophonia with co occurring OCD

    A 2025 case series gives three descriptive case studies of individuals with misophonia with co occurring OCD detailing their symptoms, diagnostic profiles, and treatment responses. All three were classified as misophonic using the Misophonia Response Scale and were also diagnosed with OCD by the author. Each patient received some combination of CBT and medication—fluoxetine, clonazepam, propranolol, or sertraline—and all showed improvement. However, it remains unclear whether these gains reflect changes in misophonia itself or simply the effects of treating co-occurring OCD. As such, the cases serve as a useful reminder of the need to distinguish misophonia-specific mechanisms from symptoms driven by comorbid conditions like OCD. (Shamla et al., 2025 )


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    Case of incidental improvement of Misophonia symptoms via Risperidone

    in a 2022 report, Pan et al describe the case of a patient who’s Misophonia symptoms improved following a Risperidone treatment. the patient was a 32-year-old male with ASD, intellectual disability, generalized anxiety disorder, and schizoaffective disorder who was Admitted via the emergency department for acute-onset paranoia and delusions during an outpatient-initiated olanzapine tape. During the course of treatment, Risperidone was administered and incidentally the patient reported reductions in existing Misophonia symptoms at a time when no other pharmacological changes were occurring. this reduced severity is further indicated by a change in his AMISOS-R scores from 31 (sever Misophonia ) to 5 ( sub clinical). although symptoms improved they di not disappear completely, and the authors urge future research to use clinical control trials to evaluate the efficacy of this approach, as the effects reported were not predicted and the mechanism by which the drug could have improved Misophonia symptoms is unknown (Pan et al., 2022).


    ## Stimulation + behavioral methods

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    Both neurostimulation (TMS) and cognitive regulation alone both help with distress, but found differing results in what worked best alone for dealing with different things

    • in a 2024 TMS study looking at the effects of neurostimulation and cognitive restructuring on emotional distress in individuals with misophonia and emotional dysregulation, Neacsiu found that both cognitive restructuring and neurostimulation on its own helped with subjective distress. the combined approach reduced self reported distress and tonic arousal.
      • however, for the single method approaches, self reported distress responded better to cognitive restructuring alone, while tonic arousal responded better to TMS alone
      • the combo approach is likely the best approach to use when possible. (Neacsiu et al., 2024)
  • Neurostimulation + behavioral/pharmacological approach

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    Dheerendra & Ramesh 2025 Iron dysregulation model of Misophonia

    in a 2025 hypothesis, article Dheerendra & Ramesh proposes a novel model of Misophonia suggesting that misophonia arises from a self-perpetuating cycle of iron dysregulation in the mirror motor cortex. Chronic hyperactivity in this region, particularly the orofacial area involved in action mirroring, leads to increased metabolic demand and elevated cerebral blood flow, facilitating excessive iron accumulation. This iron buildup induces oxidative stress and low-grade neuroinflammation, which in turn promotes maladaptive long-term potentiation and reduces inhibitory control. The resulting disinhibition enhances connectivity with sensory cortices, reinforcing pathological hyper-mirroring and involuntary mimicry of trigger sounds. This cycle sustains and exacerbates misophonic symptoms. The authors propose that targeting this loop through neuroimaging, iron-modulating treatments, or neural modulation could offer promising therapeutic interventions. (Dheerendra & Ramesh, 2025)


    8. Proposed / Theoretical Treatments

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    Mediation of the misophonia–childhood trauma relationship as support for prioritizing skills training and the use of Dialectical Behavior Therapy as misophonia interventions

    A 2026 study found that the presence of emotion regulation difficulties mediated the relationship between childhood trauma and misophonia severity. They go on to describe how the findings of impulse control difficulties being a key link suggests that the management of sudden, intense emotional behavioral reactions should be prioritized in misophonia interventions, suggesting Dialectical Behavior Therapy as one approach, given its strong emphasis on distress tolerance and impulse control skills (Kılınçel et al., 2026) .


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    Targeting early maladaptive schemas for Misophonia intervention

    in a 2026 study of 72 Misophonics and 72 controls, Fazi et al found a predictive role of early maladaptive schemas in predicting Misophonia variation, with entitlement and emotional inhibition arising as the most relevant predictors. Based on these findings the authors propose that interventions such as schema therapy or metacognitive interpersonal therapy may be possible interventions for Misophonia, with Entitlement work targeting rigid expectations of others' behavior and Emotional Inhibition work aiming to enhance emotional awareness, expression, and regulation (Fazi et al., 2026).


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    Kurt Tunagur support for acceptance based treatment of Misophonia

    Kurt Tunagur et al. (2025) administered the A-MISO-S, DASS-21, and CERQ-SF to 200 Turkish medical students and identified low acceptance as a stronger predictor of misophonia severity in males and putting into perspective as a stronger predictor in females. They recommended acceptance-based approaches such as Acceptance and Commitment Therapy (ACT) for males to reduce resistance to distressing internal experiences, and emotion-focused approaches such as Emotion Regulation Therapy, Dialectical Behavior Therapy, or self-compassion training for females when putting into perspective reflects emotional minimization rather than adaptive reappraisal. The authors concluded that misophonia-specific therapies (sound desensitization, trigger exposure with response prevention) could be augmented with these cognitive-affective components, with CERQ-based individualized assessment guiding treatment selection (Kurt Tunagur et al., 2025).


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    support for psychology-based therapeutic approaches (CBT) to Misophonia

    in a 2026 study, Ajmera gave support for psychology-based therapeutic approaches by showing that misophonia is characterized by dysfunction in salience and frontoparietal control circuits, which are involved in emotional reactivity, attentional allocation, and cognitive control. They then suggest suggest that this pattern indicates that interventions targeting emotion regulation, attentional shifting, and cognitive reappraisal (core components of therapies like CBT) are well-aligned with the observed underlying neural disruptions and may help normalize maladaptive connectivity driving misophonic responses. (Ajmera et al., 2026)


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    Characterizing real time course of Misophonic responses

    In a 2026 study, Shan attempted to characterize real-time emotional responses to misophonia triggers in naturalistic settings and examine their temporal dynamics and individual variability, by having 40 adults with misophonia complete smartphone surveys five times daily for 10 days, rating 16 negative emotions during both trigger and no-trigger periods. They found that triggers elicited significant elevations in negative emotions (particularly irritability and anger, with large effect sizes), most emotions returned to baseline within 31-60 minutes, but substantial individual variability existed in both reactivity magnitude and recovery speed, with greater reactivity associated with higher baseline negative affect, misophonia severity, and co-occurring psychopathology. From this they concluded that misophonia involves phasic context-dependent emotional reactivity centered on anger rather than chronic distress or primarily fear-based responses, and that treatment should move beyond one-size-fits-all fear-based approaches toward personalized, process-based interventions targeting individual emotional patterns, anger regulation, and distress tolerance. (Shan et al., 2026)


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    anxiety sensitivity and mindfulness as assessment and intervention targets for misophonia in OCD populations

    In a 2026 study, Karaytuğ examined the severity of misophonia symptoms in individuals with obsessive–compulsive disorder and tested whether anxiety sensitivity and mindfulness mediated the relationship between OCD symptom severity and misophonia. The findings suggest that evaluating anxiety sensitivity and mindfulness may enhance clinical assessment by identifying cognitive-emotional factors associated with misophonia symptoms in OCD. Anxiety sensitivity emerged as a central factor in misophonic responses, indicating it may be an important target in case formulation and intervention planning. Although secondary to anxiety sensitivity, mindfulness may also contribute to understanding emotional reactivity and regulatory capacity, supporting the integration of exposure-based and mindfulness-informed approaches in treatment (Karaytuğ et al., 2026).


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    Context-Dependent Reactions Require Personalized Treatment Approaches

    In a 2024 study, Woolley attempted to characterize the onset, symptom progression, triggers, and psychiatric comorbidities in treatment-seeking adults with misophonia by conducting structured clinical interviews (Duke Misophonia Interview and DIAMOND) and administering self-report questionnaires to 60 adults meeting clinical criteria for misophonia. They found that Context matters for 97% of participants, with triggers from known people (85%), internal factors like stress or fatigue (80%), and quiet environments (70%) most exacerbating. Only 3% reported context-irrelevant reactions, highlighting the specificity of misophonic distress and distinguishing it from conditions like hyperacusis. Internal states significantly influence symptom intensity, consistent with patterns in other psychopathology. Personalized, flexible interventions should address unique triggers, contextual factors, and individual clinical histories, potentially incorporating multidisciplinary approaches combining cognitive-behavioral strategies with audiological interventions and environmental accommodations (Woolley et al., 2024).


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    Berger 2024 discussing the potential therapeutic implications of incorporating social cognitive aspects of Misophonia

    In their 2024 literature review on misophonia and the role of social cognition, Berger outlines several therapeutic implications of adopting a social cognitive framework. One key implication is the need to examine whether neurobiological and physiological responses to trigger sounds change when the context in which those sounds are perceived is altered. Re-framing a trigger sound within a different interpretive context may reduce the severity of misophonic reactions, and training individuals to actively re-frame triggers could therefore serve as a viable treatment strategy. Supporting this idea, research in non-misophonia participants has shown that stress responses to unpleasant sounds such as nails on a blackboard are reduced when the sounds are presented as contemporary music. Interventions that emphasize contextual reinterpretation rather than the acoustic properties of the sound itself may also extend to misokinesia, the visual analogue of misophonia, and preliminary evidence for the effectiveness of cognitive behavioral therapy suggests that context plays a central role in shaping aversive responses (Berger et al., 2024) .

  • 9. Treatment Moderators & Predictors

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    Schroder 2017 findings on the use of CBT to treat Misophonia

    In a 2017 study ( the authors claim it the first treatment study for Misophonia) of 90 patients, Schröder et al. demonstrated that group CBT is an effective treatment for misophonia, with 48% meeting response criteria and 9% achieving remission. Symptoms significantly decreased (mean A-MISO-S from 13.6 to 9.1), with no improvement during the waitlist period. Greater baseline severity and the presence of disgust (vs. anger alone) predicted better outcomes (OR = 2.576, p = .038). The authors concluded that CBT techniques like counterconditioning and stimulus manipulation effectively target core misophonia symptoms. (Schröder et al., 2017)


    10. Field-Level Gaps & Future Directions

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    review of variability in outcome measures across Misophonia studies

    Across the seven studies reviewed by Aazh (2026), misophonia outcome measurement was highly heterogeneous, with both clinician-rated and self-report instruments employed and only the Amsterdam Misophonia Scale family (A-MISO-S / AMISOS-R) used in more than one study reviewed. Most instruments were multidimensional (assessing combinations of emotional, behavioral, and functional impacts) , though some emphasized specific constructs such as functional impact (Misophonia Impact Questionnaire, MIQ) or symptom severity (Sound Sensitivity Symptoms Questionnaire, SSSQ), and one study relied on a general anger measure (Novaco Anger Scale). The author suggest that this variability limits direct comparison across studies , emphasizing the need for a core set of pre defined outcomes outcome set for future clinical trials (Aazh, 2026).


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    CBT studies need to strengthen methods to confirm efficacy in misophonia

    In a 2026 study, Detroy conducted a focused scoping review of CBT applications to misophonia by synthesizing 14 in-depth studies and summarizing 16 additional reports drawn from a PRISMA-ScR-guided search yielding 30 included publications. They concluded that CBT-family procedures are deliverable and potentially helpful for misophonia while falling short of firm efficacy claims, and that future studies should adopt core outcome batteries, specify procedures at a granular level, and test which components contribute uniquely to clinically meaningful change (Detroy & Norena, 2026).


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    tailoring cognitive interventions to address self-blame, external attribution, and post-trigger rumination in misophonia

    In a 2026 study, Woolley aimed to qualitatively characterize negative cognitions during and after misophonia triggers by analyzing open-ended interview responses from 60 treatment-seeking adults using inductive content analysis. They found that during triggers, participants reported self-criticism, appraisals of others as rude, intrusive aggressive thoughts, and escape-focused cognitions, while after triggers they described regret, guilt, and intrusive memories of prior sounds, though 20-40% denied experiencing cognitive processes. From this they concluded that negative cognitions extend misophonia-related distress beyond immediate sound exposure through post-event rumination and intrusive memories, but meaningful heterogeneity exists in cognitive involvement, suggesting interventions should be tailored to target specific patterns including self-blame, external attributions, and ruminative processing (Woolley et al., 2026a).


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    Muñoz et al. 2025 literature review findings and implications for treatment approaches of Misophonia moving forward

    A 2025 literature review of behavioral and audiological treatment approaches for misophonia found that behavioral treatments, particularly those based in cognitive behavioral therapy (CBT), show promise in reducing symptom severity. However, the review noted a lack of integration of audiological assessment in misophonia treatment research. Given that misophonia often begins in childhood, the authors emphasized the importance of timely assessment and interdisciplinary treatment involving both audiology and psychology. For future directions, they recommended standardizing audiological evaluation in misophonia research, expanding the use of randomized controlled trials and studies with active comparison groups, investigating the impact of auditory comorbidities such as tinnitus and hyperacusis on treatment outcomes, developing validated assessment tools for pediatric populations, and fostering interdisciplinary collaboration in treatment planning. (Muñoz et al., 2025)


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    difficulties with emotional regulation as a a core trait of Misophonia and a possible differential diagnostic factor for Misophonia vs hyperacusis

    In a 2025 study, Aryal examined whether difficulties with emotion regulation differentiate misophonia from hyperacusis by assessing the relationship between emotion regulation and symptom severity in adults with clinically significant misophonia using self-report questionnaires. They found that greater difficulties with emotion regulation were associated with greater misophonia but not hyperacusis severity after controlling for age and the other sound intolerance condition; misophonia severity was specifically related to difficulties with goal-directed behavior, impulse control, access to strategies, and nonacceptance. From this they concluded that difficulties with emotion regulation may be a clinical feature that differentiates misophonia from hyperacusis and that interventions targeting emotion regulation may be useful in the treatment of misophonia (Aryal et al., 2025).


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    future directions for maladaptive early schemes in Misophonia

    In a 2023 study, Stalias-Mantzikos et al. examined early maladaptive schemas (EMS) in misophonia, identifying patterns that both overlap with and distinguish it from related comorbidities. They note that future research should prioritize replication with larger and more diverse samples, particularly increasing representation of non-binary individuals and focusing on specific schemas. They also emphasize the need for controlled studies comparing individuals high in misophonia with healthy controls. Additional directions include examining how insufficient self-control relates to symptom duration, and investigating the longitudinal relationship between social withdrawal and misophonic distress. The authors further suggest exploring the roles of intolerance of uncertainty and perfectionism as transdiagnostic factors, as well as clarifying the relative contributions of neuroticism and EMS to symptom severity. Finally, they highlight the absence of empirical work on schema therapy for misophonia and recommend that future studies directly evaluate its effectiveness (Stalias-Mantzikos et al., 2023).


    # 11. Treatment §11. Patient & Family Treatment-Seeking Experiences -

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    Rodriguez-Barajas 2026 themes in those seeking Misophonia treatment

    Rodriguez-Barajas et al. (2026) conducted semi-structured interviews with 20 youth with misophonia (ages 10–17) and their parents, analyzing transcripts using reflexive thematic analysis to characterize treatment-seeking experiences. the reported experiences were predominantly negative, with Six negative themes emerging centering on minimal provider awareness, scarcity of knowledgeable professionals, limited general resources, absence of standardized treatment protocols, frequent misdiagnosis (most commonly anxiety, ADHD, or OCD), and barriers stemming from the lack of an official diagnostic code in major classification systems. The authors also identified two positive themes, namely relaxation and validation from providers, with the latter characterized by feelings of relief, hope, and decreased distress when clinicians acknowledged misophonia as a genuine condition (Rodriguez-Barajas et al., 2026).


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    common approaches to care giving and typical care providers in Misophonia

    Molthrop et al. (2026) surveyed 22 US caregivers of individuals with misophonia about the strategies and providers they had used, and found that environmental and avoidance-based approaches were the most common, with home rearrangement, modified event planning, and active noise cancelling each endorsed by over three-quarters of the sample, followed by supportive therapy, passive noise cancelling, anti-anxiety medication, regular sleep schedules, and school accommodations. Among families who had sought professional care, most had seen more than one provider, with audiologists most frequently consulted, followed by mental health therapists, occupational therapists, psychologists, psychiatrists, and primary care providers. Despite this breadth of strategies and providers, mean treatment satisfaction was very low, and caregivers described existing approaches as offering coping rather than meaningful symptom reduction (Molthrop et al., 2026).


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    major barriers to care in Misophonia

    Molthrop et al. (2026) surveyed 22 US caregivers of individuals with misophonia and asked them to rank barriers to care alongside open-ended commentary, finding that provider shortages and access were the most frequently endorsed top barrier, followed by stigma, lack of awareness or education, financial burden, and inadequate insurance coverage. Although financial barriers ranked lower in the forced rankings, qualitative responses indicated that cost still meaningfully hindered treatment access, with families citing the expense of weekly therapy, out-of-pocket payment for private interventions, and lost income from caregiving and travel to distant providers. Caregivers also described a striking lack of misophonia awareness among healthcare and mental health clinicians, leaving families to navigate care without informed guidance. From this the authors conclude that improving access to misophonia care will require expanded provider training, broader public and clinical education to reduce stigma, and greater financial accessibility of mental health treatment more generally (Molthrop et al., 2026).


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    novel finding of financial impact of Misophonia and its implications

    Molthrop et al. (2026) identified a novel Financial Impact theme in their survey of 22 US caregivers of individuals with misophonia, with families describing treatment and accommodation costs as major expenses, including weekly private therapy, home modifications, lost work time, and travel to distant providers, compounded by inadequate insurance coverage given misophonia's lack of formal diagnostic recognition. Notably, financial strain occurred across income brackets rather than tracking neatly with earnings, suggesting care costs can outpace family resources even at higher incomes. From this the authors suggest future work should target more financially strained samples and that improving the financial accessibility of misophonia treatment should be a clinical and research priority (Molthrop et al., 2026)
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    self reported treatment approaches in misophonia

    Rodriguez-Barajas et al. (2026) interviewed 20 parent-child dyads (youth ages 10–17) about their experiences seeking care for misophonia and documented the range of strategies families pursued in the absence of standardized treatment. Parents reported experimenting with medications approved for other psychiatric conditions in hopes of symptom reduction, engaging with various psychological therapies, and relying heavily on community resources such as Facebook support groups, which were identified as the most practically useful source of provider referrals and psychoeducation. Relaxation techniques including deep breathing, mindfulness, and progressive muscle relaxation were described by some participants as helpful for reducing distress following trigger exposure, though the authors cautioned that such strategies are unlikely to be sufficient long-term given the biopsychosocial complexity of misophonia (Rodriguez-Barajas et al., 2026).


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    common obstacles for those seeking Misophonia treatment

    Rodriguez-Barajas et al. (2026) interviewed 20 parent-child dyads (youth ages 10–17) seeking care for misophonia and identified several recurring obstacles across their treatment-seeking experiences. Families reported that providers across disciplines, including pediatricians, psychiatrists, neurologists, and audiologists, were frequently unfamiliar with misophonia, often leading families to educate providers themselves, and the absence of a formal diagnostic code in the Diagnostic and Statistical Manual of Mental Disorders (DSM) or International Classification of Diseases (ICD) compounded these difficulties by limiting insurance coverage and blocking access to school-based accommodations such as 504 plans. The authors concluded that these structural barriers, combined with low professional awareness, create a prolonged and emotionally costly trial-and-error process that significantly delays access to appropriate care (Rodriguez-Barajas et al., 2026).