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2014 report of successful Misophonia treatment using tinnitus retraining therapy

In a 2014 study, the Jastreboffs' proposed and evaluated a treatment approach for decreased sound tolerance (DST), distinguishing between hyperacusis and misophonia and targeting each with tailored protocols within the framework of Tinnitus Retraining Therapy (TRT). Hyperacusis was treated through gradual sound enrichment to reduce central auditory gain, while misophonia was addressed using behavioral conditioning techniques to weaken maladaptive reflexive responses to specific sounds. Their clinic at Emory University treated 201 patients using these methods, achieving significant improvement in 82% of cases overall, including 80% of those with hyperacusis and 83% of those with misophonia, thereby providing strong clinical support for the neurophysiological mechanisms underlying these conditions. (Jastreboff & Jastreboff, 2014)