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McMahon 2024 showing successful misophonia treatment via a unified protocol

In a 2024 pilot study, McMahon et al. evaluated misophonia treatment using the Unified Protocol (UP), a transdiagnostic CBT targeting emotional intolerance and avoidance. Study 1 showed moderate to high acceptability, significant reductions in emotional/behavioral misophonia responses, anxiety, and anger, small improvements in symptoms and severity, no effect on depression, and medium improvements in maladaptive beliefs (DMQ). Study 2 demonstrated high acceptability and perceived helpfulness, with large effects on emotional/behavioral responses, misophonia severity, and anxiety; medium effects on symptoms and anger; small effects on depression; and maintained or increased gains at follow-up. The authors concluded that the UP is a feasible, acceptable, and promising intervention, particularly effective in reducing emotional reactivity and avoidance. (McMahon et al., 2024)