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N1 amplitude reductions as a candidate Misophonia biomarker

Karupaiah et al. (2025) found selectively reduced N1 amplitudes across all midline electrode sites (Fz, Cz, Pz) in misophonic adults relative to controls using a non-trigger speech stimulus, with P1 and P2 amplitudes remaining unaffected. This selective N1 reduction replicates Schröder et al. (2014) findings in there oddball study using pure tones, and the authors argue the consistency of this effect across paradigms and stimulus types strengthens its candidacy as a neurophysiological biomarker of misophonia. However, they note that future work incorporating trigger-specific stimuli is needed to determine whether the reduction reflects a generalized auditory cortical difference or is amplified by emotional salience (Karupaiah et al., 2025).