Body

physiological signals + behavior as diagnostic and se4verity measures

In a 2025 study, O'Reilly and colleagues found that while some individuals with misophonia exhibited strong physiological responses to trigger stimuli, especially in EMG, EDA, and ECG measures, others showed little to no response, reflecting substantial inter-individual variability. These responses correlated with subjective distress ratings and were most pronounced in the misophonia group, though machine learning models using physiological data alone could not reliably classify group membership. The authors concluded that misophonia may involve broader sound intolerance and that physiological signals especially when combined with behavioral data, could serve as useful adjuncts for diagnosis and severity assessment. (O’Reilly et al., 2025)